The horror crash happened on the A57 Sheffield Parkway at around 1.24am today. It is reported Mohammed Munib Majeedi fell from a ninth-floor room where he was staying with his mother. But you're all here to show your respect.". Video1894 shipwreck confirms tale of treacherous lifeboat, How 10% of Nigerian registered voters delivered victory, Sake brewers toast big rise in global sales, The Indian-American CEO who wants to be US president, Blackpink lead top stars back on the road in Asia, Exploring the rigging claims in Nigeria's elections, 'Wales is in England' gaffe sparks TikToker's trip. 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Send your story ideas to yorkslincs.news@bbc.co.uk. The road was closed from 9pm on December 9, The latest Sheffield news and updates delivered to your inbox. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. Or by navigating to the user icon in the top right. Two suspected murderers are due to appear at Sheffield Crown Court today, Tuesday, February 28, after the death of Sarah Brierley at a property in the citys Woodhouse neighbourhood. This work has provided important evidence in support of a completely new strategy to treat the most common inherited cause of both MND and FTD, with the ultimate goal of developing effective therapies for these devastating diseases.. Something went wrong, please try again later. Welcome back Edit Account-Sign Out. The new study, conducted by researchers at the University of Sheffields Institute of Translational Neuroscience (SITraN), also showed that using a peptide to stop the transport of mutant repeated RNA molecules and production of toxic repeat proteins actually increases the survival of C9ORF72 nerve cells - protecting them against neurodegeneration. A woman has died after being found "on fire" in a Sheffield park. It is hoped the innovative research, conducted in collaboration with multiple labs in SITraN and with the groups of Dr Alexander Whitworth (University of Cambridge), Dr Cyril Dominguez (University of Leicester), Professor Frdric Allain (ETH Zurich) and funded by the MND Association and the UKRI BBSRC and MRC councils will transform the future of clinical trials for the most common forms of MND and FTD within the next few years. At the scene today, Mr Bennett told Sky News: "I'm broken, I just want to kiss my babies. Chief Constable Rachel Swann described the deaths as a "shocking event". Dr Brian Dickie, Director of Research at the MND Association, said: These findings from a world leading research team in Sheffield demonstrate the importance of funding fundamental discovery science. Professor Guillaume Hautbergue, Professor of Translational RNA Biology at the University of Sheffield, who led the study said: When we tested our innovative approach by adding the peptide to the food eaten by fruit flies not only did the peptides block the damaging mutations which cause MND and FTD from being transported to the cell's nucleus, we actually saw an improvement in their neurofunction. "Each one of you is here to remember four people who are no longer with us," he said. ", She thanked the officers who arrived to the scene "in such a difficult situation" and added: "While understandably worrying and upsetting, this is believed to be an isolated incident in which those involved were known to one another and nobody else is being sought in connection with the deaths.". WebLive Sheffield news, including the latest headlines on travel, crime, local politics, M1 updates, events and much more on South Yorkshire's largest settlement. The Sheffield driver and his passenger both made gestures towards a speed camera van. Follow BBC East Midlands on Facebook, Twitter, or Instagram. Wills. John Paul and Lacey's father Jason Bennett said "life will never be the same again", Lacey and John Paul's mother Terri Harris was found dead at the house, Local residents have been lighting candles at St Giles Church, Specially-trained officers are liaising with the families of the deceased, Flowers have been left near the police cordon on Chandos Crescent, People started gathering for a candlelit vigil in the local park earlier on Monday night, Mourners also left flowers and teddies alongside the candles. A cordon was in place in High Hazels Park, Darnall yesterday. "She was screaming, 'my son, my son'. Office: 01-142-229-859, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Biomolecules/, /Life sciences/Biochemistry/Biomolecules/Proteins/, /Life sciences/Biochemistry/Biomolecules/Proteins/Membrane proteins/, /Life sciences/Neuroscience/Cellular neuroscience/Neurons/, /Social sciences/Psychological science/Clinical psychology/Cognitive disorders/, Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The groundbreaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of MND and FTD. The council will be renewing its nine Public Space Protection Orders until 2026. A five-year-old Afghan refugee who fell to his death from a Sheffield hotel window has been identified by police. The man, who worked as an interpreter for the British Army in Afghanistan, said one of his children alerted him to the boy falling and he went outside to help. Killamarsh is a community in mourning and disbelief, according to the Rev Canon Helen Guest, rector at St Giles Church. "I don't know how he's going to come through this.". WebSheffield & South Yorkshire. Emergency services were called to the OYO Sheffield Metropolitan Hotel on Wednesday afternoon, South Yorkshire Police said it was not treating the death as suspicious. A man found unconscious in Sheffield city centre in the early hours of Saturday morning has tragically died in hospital. Read about our approach to external linking. 2023 BBC. News. The woman was sadly pronounced dead at the scene. The British Library, London. They said that they were called following reports of "concern for a woman" who was sadly pronounced dead at the scene. The woman has not been identified but the force said it is treating her death as suspicious. This concept of using peptides to block destructive mutations unlocks such an exciting and innovative treatment pathway which until now has not been explored by scientists. are not responsible for the accuracy of news releases posted to EurekAlert! "The area was cordoned off while enquiries were conducted. Sign up to our newsletter for free Sheffield updates and breaking news by email. Call 101, quoting incident number 853 of December 9 or Crimestoppers on 0800 555 111. The crash happened on December 9 at around 9pm and involved a black Toyota MR2 which was travelling along Hanover Way towards Moore Street roundabout. Database with images. The third child has been named as Connie Gent, 11, from Sheffield. Sheffield City Council leader Terry Fox said: "This is absolutely devastating, just so incredibly sad. Sheff Utd. "And it is a day that we'll all remember because this doesn't happen in Killamarsh. A man was found unconscious in Pond Street. The BBC is not responsible for the content of external sites. 2023 BBC. A man found unconscious in Sheffield city centre in the early hours of Saturday morning has tragically died in hospital. Senior investigating officer Andy Knowles said: "We are continuing our inquiries at pace to ensure that every piece of detail surrounding Sarah's death is obtained and investigated. Read about our approach to external linking. "He was transported to hospital but sadly died a short time later. Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia Researchers from the University of Sheffields Institute of "The police are providing support to the family while the investigation continues and we cannot comment further at this time. **Strictly embargoed until 19:00 (GMT) Wednesday 1 March 2023**, Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia. The Universitys four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions. A woman has died after being found "on fire" in a Sheffield park. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. David Scott, 39, and Zoe Clarke, 38, both of Woodhouse, Sheffield, have been charged with the 49-year-old's murder and remanded in custody, South Yorkshire Police said. Harry and Meghan told to 'vacate' Frogmore Cottage, Explosive found in check-in luggage at US airport, Fungus case forces Jack Daniels to halt construction, Rare Jurassic-era bug found at Arkansas Walmart, China and Belarus call for peace in Ukraine. Follow South Yorkshire Live or My Sheffield on Facebook and Twitter for the latest Sheffield news and follow Yorkshire Live on Instagram for beautiful images and stories. The man said the eight to 10 Afghan families staying at the hotel were being moved to another hotel on Thursday afternoon. WebFollow the latest news for Sheffield in South Yorkshire, England, UK - Local news and information in your area Latest News in Sheffield in South Yorkshire, England, UK - Read about our approach to external linking. Posted. Posted. FamilySearch. What has happened here, therefore, raises some serious questions about what steps were taken to ensure the hotel was safe for vulnerable families and young children and about the state of accommodation being provided to asylum seekers. Sheffield, Yorkshire. He was later asked to accompany Mohammed's mother to hospital to translate. The death is not being treated as suspicious.". The BBC is not responsible for the content of external sites. a.l.pullan@sheffield.ac.uk Send your story ideas to yorkslincs.news@bbc.co.uk. There had been concerns raised about the safety of the windows. Copy Citation. Many of those arriving to pay their respects had young children themselves. WebSheffield-born man killed in USA car accident Doncaster-filmed Open All Hours actress Lynda Baron dies aged 82 Tributes pour in for popular footballer killed in crash Much Media contact: For more information please contact: Amy Huxtable, Media and PR Officer, University of Sheffield, 07568116781, a.l.huxtable@sheffield.ac.uk, A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration. "We can't believe this tragedy has happened in our community and it's literally a stone's throw from where I live," she said. A post-mortem examination is due to take place in the coming days. She said officers were particularly keen to speak to anyone who was in Chandos Crescent between 21:30 BST on Saturday and 07:30 BST on Sunday, and had any information that could help with their investigation. Following the vigil he told the BBC: "Many of them wanted to be able to come and show their feelings for one another, for the community and to be there to support one another. Harry and Meghan told to 'vacate' Frogmore Cottage, Explosive found in check-in luggage at US airport, Fungus case forces Jack Daniels to halt construction, Rare Jurassic-era bug found at Arkansas Walmart, China and Belarus call for peace in Ukraine. The city is also home to Sheffield Arena, a popular venue, and the large shopping centre Meadowhall. This concept of using peptides to block destructive mutations unlocks such an exciting and innovative treatment pathway which until now has not been explored by scientists. "It is vital the Home Office carry out an urgent investigation into what has happened so steps can be taken to quickly learn lessons. Professor Guillaume Hautbergue, Professor of Translational RNA Biology at the University of Sheffield, who led the study said: When we tested our innovative approach by adding the peptide to the food eaten by fruit flies not only did the peptides block the damaging mutations which cause MND and FTD from being transported to the cell's nucleus, we actually saw an improvement in their neurofunction. This work has provided important evidence in support of a completely new strategy to treat the most common inherited cause of both MND and FTD, with the ultimate goal of developing effective therapies for these devastating diseases.. South Yorkshire Police have sealed off Castle Square and Esperanto Place in the city centre after officers were called to the scene shortly after 3am on November 6. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. In a statement on Twitter, the school said: "It is with great sadness that the academy will be closed today. They found the bodies of the three children, along with that of 35-year-old Terri Harris, who was Lacey and John Paul's mother. "As a council we are in close contact with the police and will provide any support that we can to the family - my heart goes out to them.". The Sheffield team previously discovered the abnormal transportation of the rogue RNAs copied from the C9ORF72 gene - known to be the most frequent cause of MND and FTD - is caused by excessive stickiness of a cell transporter named SRSF1. The peptide is composed of a short chain of amino acids or bricks found within our cells and tissues in the body. South Yorkshire Police said the body was discovered at an address in "I just want to kiss them and hold them. The BBC is not responsible for the content of external sites. "So far we've had a gentle flow of people who are coming in," said the rector. A man was found unconscious in Pond Street, Sheffield, in the early hours of Saturday November 6. A five-year-old Afghan refugee who fell to his death from a Sheffield hotel window has been identified by police. "Sadly, the woman was pronounced dead at the scene. Mrs Bennett said Lacey was a West Ham fan and John Paul liked TikTok and computers. The BBC is not responsible for the content of external sites. The force has appealed for anyone who witnessed the incident to contact them. View. It also left three other people needing ", Derbyshire Police's chief constable Rachel Swann said the deaths were an "understandably shocking event that has deeply affected the local community in Killamarsh, as well as colleagues, family and friends in Sheffield. Blades ready to 'fight and scrap' for promotion. "His mother was in the room with him," he said. FTD most commonly affects people aged 45-65 and can affect behaviour, personality, language and movement. 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